Yeah from my experience running quizzes on reddit and tracking stats for which ones were correctly guessed, 'cinematic orchestral soundtracks' were consistently one of the most poorly performing genres.
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They sound too similar to each other, making it very hard to guess one from the 200 other games which have music which sounds the same to non-specialists. Popular retro games, JP games, indie games, and AA western OSTs tend to have more recognizable and distinct styles that aren't just "make it sound like Hans Zimmer".
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They lack cultural penetration. The Halo theme is very famous, but compare the number of arrangements/covers you see of Undertale songs to, say, Elden Ring. Yeah Elden Ring is an immensely popular game, but popular game =/= recognizable music.
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They don't stand out, by design. Most are textural or set the mood, and deliberately avoid being catchy or attention grabbing. I think even a fan of the game would be hard-pressed to remember the songs from these games, or where they actually play, with only some exceptions.
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They tend to be slow and methodical, with long builds and releases, and are thus extremely hard to capture within a little 15 second clip. I know I scrapped several popular orchestral pieces in my quiz making days just because I couldn't find a good mini-clip to use.
Aside from that though, it also depends on the guests you have. For certain groups of people, certain songs are considerably easier or harder. Take the vgm community here for example... the Trails series is very popular here, so something like Sophisticated Fight ( https://www.youtube.com/watch?v=Um5EbReY7rA ) would be considered "easy" and almost everyone you showed it to would probably be able to at least name the series. And yet, I wouldn't be surprised if 5 of the 6 guests you've had on so far hadn't even heard of the game, let alone have any hope of guessing the song. Inversely, there is some songs in your quizzes where all three of your guests knew what it was, but I had never heard the song before =P There ARE groups out there which would know the TLOU song easily, but this group of guests happened to not be it.
Also in spite of the all that, I still regularly used that sort of music. I saw my vgm quizzes as a way to celebrate vgm and games in general, and so it was very important to me that they represented a lot of what vgm had to offer. There's people who love these games and this music, and some of the most revered games ever have music in that style, so and I wanted them to be represented as well.
In your case, even though your guests didn't know what the TLOU song was, maybe some of your ~180 viewers did, and were super glad to see it there. The Atelier song is another good example here too... I got the impression you were inwardly apologizing for it being there, because you perhaps correctly guessed that the group wouldn't have even heard of the game, let alone had any hope of guessing it... but hey, I knew the series and got it half correct, and I was super happy that someone actually nominated a Gust song <3
The trick is to build an intuition for what songs and parts of songs are most recognizable. The fact you used The Last of Us's main theme was definitely an example of what I'm talking about, though perhaps not quite enough in this case.
If you really want at least one of your guests to know every song, then I'd say to tailor your picks for the background of your guests, though I don't know if you know who you'll have on until right before the game, so I imagine that might make things difficult.
Ultimately though it's your show and you should run it how you want and make the selections you want to make. I think you'd lose something if you excluded an entire genre of music and game, but... yeah.