I admit Kingpin has basically run his course as a Spidey villain (although he is the intro villain to the Insomniac game) as they've transitioned him into being more affiliated with Daredevil, but he played a big part in Spidey stories in the 90s, which is what a lot of us remember most.
But Spidey has such a great catalogue of rogues that have each had their own time in the spotlight that you can make legitimate arguments for several characters being on the Mount Rushmore.
https://imgur.com/WqDcNNq
https://imgur.com/89Z5jrB