Master Sword (Zelda)
Buster Sword (FF7)
BFG (Doom)
Pickaxe (Minecraft)
Minecraft's pickaxe is so big entire genres spawned with it as a weapon and tool combination. you don't get Fortnite without it, craft builders, or a million survival games. iconic as it gets really.
"Maybe it's a tentacle, molesting the planet itself. - Aschen Brodel.