Lurker > Iubaris

I play the game a lot. Now is a fantastic time to jump in. The expansion is a huge boon to new players. Instead of repeating 4 acts 3 times, there's now 10 acts with a continuous storyline, with a smooth introduction into the end-game mapping system. In addition, they've added a sorely-needed help/tutorial thing ingame.

If you're new, you can either just jump in and just build how you want, or you can follow a guide on the official forums. It really depends on the kind of player you are.

The act 5 boss is a pretty large jump in difficulty, but it's definitely solo-able, the whole game is. I've been playing for about two years and I never party with anyone.
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It's iubaris, not Lubaris.