The 3DS may do well but it will have some problems. For one, they are asking people to shell out 250 (and soon 170) for a system that replaces the $130 system they just bought. You're also asking the casual entrants to the handheld gaming market to hop into the world of 3D gaming, and that won't go so well.
It'll sell pretty well and all, but I'd be surprised if it can catch fire like the DS did.
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Donny: Are they gonna hurt us, Walter?
Walter: No, Donny. These men are cowards.