I've read that the Diablo III hands-on is amazing. Someone on the DIII board was a big time hater about the graphics style and basically within seconds you don't care about them. Not that anyone should have cried about that (or the RMAH) in the first place.
But any gameplay issues people have been worried about seem to be "nothing to worry about"
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Donny: Are they gonna hurt us, Walter?
Walter: No, Donny. These men are cowards.