I've never seen a good female stand-up tbqh. And I think it's more than that. Females are just less often portrayed with the qualities that most people find likable - honesty, dedication, humility, a sense of humor, etc. And even when they ARE, their natural... I dunno, shrillness (hell, we may as well call it "being a woman") might STILL make them less likable than their main counterparts. Hell, Skylar White is almost surely the least liked main character on Breaking Bad.
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Yoblazer: http://oi52.tinypic.com/ad21i1.jpg
Watch and you'll see... someday I'll be... part of your world!