Well for all their failing, they've only actually died twice. One of those was because they loaded a previous save and fought Yakra without healing first, and the other was because they were openly experimenting with the 1999 AD bucket at the End of Time (just like everyone else did on their first playthrough I'm sure) and fully expected to die, so I'm hesitant to count that one.
So even for as bad as they are, their only legitimate Game Over has come from one instance of Ryan's jaw-dropping insistence on saving first and THEN healing up coming back to bite them.
CT is proving that it is designed well enough that even when played poorly it still works!
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Thank you, Eddie Guerrero.
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