My first time through I played the whole game on moderate.
Currently on a second play through where I am on the highest difficulty available to me (believe chaos is the last one?). Note this is not ng+ so no so bonuses or anything.
**Spoilers if you guys are still marking those.**
Had to use my first All-Divide on Emeraude. Almost did on Kurt because my AI strategies kept focusing the high health ever respawning minions, but I slugged it through. Emeraude's snap kill thing just did insane amounts of damage though.
**End Spoilers**
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