LogFAQs > #941597178

Okay so, looking at Star's wiki: https://starvstheforcesofevil.fandom.com/wiki/Star_Butterfly
She's described as friendly ("Strangers, in her eyes, are just friends she has not met yet") and apparently hates overuse/misuse of magic. So I don't think she's the type to just go around nuking random city blocks. She seems like she'd determinedly search for her opponent, willing to search for as long as it took...and probably eat some random pack of ground beef along the way.

Based on what Pirateking said, I'm inclined to believe that peak condition Star can theoretically heal prion diseases (a growing/corrupting mutation with no known cure seems as similar as you're going to get in a cartoon). The complicating factor here is that she would have the prion disease, which progressively impairs her mental function, and she'd have to realize it and come up with a solution while she still has the mental faculties to do so.

In this case, where she's effectively in isolation, I think she won't notice until it's too late. In the real world she'd have friends to point out she's been acting differently, or she'd realize her school performance is going downhill (does she go to school?) or she can no longer do her normal activities properly. Here, it's like the proverbial frog in a pot. I mean, she would eventually realize something is seriously wrong, but would she be able to perform complex magic on her own brain by then? Probably not.

the prion
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another place and time, without a great divide, and we could be flying deadly high