The leader of the Dark Judges, a sinister group of undead law enforcers from the alternate dimension of Deadworld, where all life has been declared a crime since only the living commit crimes. After years of appearing in Judge Dredd stories, he later got his own series in the Judge Dredd Megazine and in 2000 AD.Kamui (Gintama)
Kamui is always eager to fight with anyone who looks powerful, he firmly believes that the Yato are to remain on the battlefield and shows his disapproval of Housen staying locked up in Yoshiwara. Because of this belief, he shows no pity towards family or subordinates as a sign of weakness is unacceptable.Lord Antono Refa (Babylon 5)
Lord Refa is dedicated to restoring the power of the Centauri Republic through distinctly Machiavellian methods. His house is one of the most powerful in the Centarum, the Centauri Republic's ruling legislature, and he is apparently a man of great wealth and influence. As the series progresses he emerges as a sinister character. Michael Roa Valdamjong (Tsukihime)
Michael Roa Valdamjong is the main antagonist of Tsukihime. He is a vampire and a numberless Dead Apostle Ancestor ranked as "Extra" outside of the regular twenty-seven because they consider him to be a heretic who does not uphold the ideals of regular vampires.Mr. Morden (Babylon 5)
Morden serves as the spokesman on behalf of the Shadows, an ancient and incredibly powerful alien race whom he refers to as his "associates". Although outwardly polite and gracious, he represents a dangerous hidden agenda.Pycal (Lupin III)
Pycal appears to have vast scientific knowledge, as well as genuine magical skill, as he manages to craft himself a hardened second-skin to avoid burn damage as well as displaying the ability to fly and shoot fire from his fingers.Rakchasa (Supernatural)
A rakshasa is a demon or unrighteous spirit in Hindu and Buddhist mythology. Rakshasas are also called man-eaters ("Nri-chakshas," "Kravyads") or cannibals. Looked like a clown. Sarevok (Baldur's Gate)
The main antagonist, the foster son of Rieltar Anchev is in truth a Bhaalspawn fueled with great ambition and unholy might.Satan (Tenacious D - The Pick of Destiny)
Challenged to a rock off by Tenacious D and battles it out with themTakasugi Shunsuke (Gintama)
is the leader of the Kiheitai, an extremist group which he resurrected from the Joui Wars. The Kiheitai is a Joui faction bent on causing world destruction.Tetsuo Shima (Akira) http://konachan.com/post/show?md5=2e0c57371880e57099926433af8397e5 Is the main antagonist of Akira. He evolves from Kaneda's best friend and gang member to Kaneda's nemesis. He is involved in an accident at the very beginning of the story, which causes him to display immense psychic powers.
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Save my Villain Day 2 (Spoilers) *RULE CHANGE* http://www.gamefaqs.com/boards/8-gamefaqs-contests/62706736