Noob Saibot (Mortal Kombat)
Nrvnqsr Chaos (Tsukihime)
Nyarlathotep (Cthulu Mythos)
Onslaught (Marvel - 616)
Oogie Boogie (Nighmare Before Christmas)
O-Ren Ishii (Kill Bill)
Orochimaru (Naruto)
Ozzie (Chrono Trigger)
Ozzymandias (Watchmen)
Pain (Naruto)
Palpatine/Darth Sidious (Star Wars)
Pennywise (Stephen King: IT)
Petyr Baelish (A Song of Ice and Fire)
Phacia (Lunar Silver Star Story)
Piedmon (Digimon)
Poison Ivy (DC Comics)
Poseidon (Saint Seiya)
President Snow (The Hunger Games)
Prince John (Disney's Robin Hood)
Princess Alicia Acorn/Anti Sally (Sonic the Hedgehog comics)
Professor Chaos (South Park)
Professor Moriarty (Sherlock Holmes)
Professor Norton Nimnul (Chip 'n Dale Rescue Rangers)
Proto Man (Mega Man TV Series)
Psycho Mantis (Metal Gear Solid)
Puppetmon (Digimon 1)
Pyramid Head (Silent Hill)
Quan Chi (Mortal Kombat)
The Queen (Snow White and the Seven Dwarfs)
Queen Beryl (Sailor Moon)
Queen Chrysalis (MLP FIM)
Raditz (Dragon Ball Z)
Ramsay Bolton (A Song of Ice and Fire)
Randall Flagg (Stephen King, different books)
Rangda (Balinese mythology)
Raphael Sorel (Soul Calibur)
Ratigan (The Great Mouse Detective)
The Red Guy (Cow and Chicken)
Red Skull(marvel comics)
Relius Clover (Blazblue)
Rhadamantys (Saint Seiya)
Ribbons Almark (Gundam 00)
Richard Nixon (Black Dynamite)
The Riddler (Batman)
Ridley (Metroid)
Ripper Roo (Crash Bandicoot)
Rita Repulsa (Might Morphin Power Rangers)
Royce (Lunar Silver Star Story)
Roy Koopa (Mario series)
Rufus Shinra (Final Fantasy VII)
Rugal Bernstein(King of Fighters)
Saffron (Firefly)
Saiki (King of Fighters XIII)
Sailor Galaxia (Sailor Moon)
Saix (Kingdom Hearts)
Sakuya Haibara (Fatal Frame IV)
Sandman (Marvel Comics)
Sarah Kerrigan (Starcraft)
Sareena (Mortal Kombat)
Saren (Mass Effect)
Sasori (Naruto)
Saturos (Golden Sun)
Sauron - The Lord of the Rings
SA-X (Metroid Fusion)
Scanty (Panty and Stocking)
Scarecrow (Batman)
Scar (The Lion King)
Scorpina (Mighty Morphin Power Rangers)
Schneizel El Brittania (Code Geass)
Scott hall (wcw)
Scott the Dick (South Park)
Selvaria Bles (Valkyria Chronicles)
Sensui (Yu Yu Hakusho)
Sephiran (Fire Emblem 9-10)
Sephiroth (Final Fantasy VII)
Seymour Guado (Final Fantasy X)
Shadow Broker (Mass Effect)
The Shadow Queen (Paper Mario: TTYD)
Shang Tsung (Mortal Kombat)
Shan Yu (Mulan)
Shao Kahn (Mortal Kombat series)
Shelly De Killer (Phoenix Wright)
Shere Khan (Jungle Book)
Sherrif of Nottingham (Robin Hood: Prince of Thieves)
Sherry Palmer (24)
Shinnok (Mortal Kombat)
Shishio Makoto (Rurouni Kenshin)
SHODAN (System Shock)
Shooter McGavin (Happy Gilmore)
The Shredder(Teenage Mutant Ninja Turtles)
Shuyin (Final Fantasy X-2)
Sideshow Bob (The Simpsons)
Sigma (Mega Man X)
Sinestro (Green Lantern)
Sinistar (Sinistar)
Skeletor (He-Man and the Masters of the Universe)
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Randomness 26
http://www.misterpoll.com/polls/286788