Dr. Neo Cortex (Crash Bandicoot) - .
most known as Doctor Neo Cortex or simply N. Cortex, Cortex or Doctor Cortex, is a professional evil scientist and the primary antagonist of the Crash Bandicoot series. He is known as the creator of his nemesis. Cortex is very impulsive and obviously wants to get Crash Bandicoot out of the way so he can conquer the world. He is also cruel to Doctor N. Gin, as shown in Crash of the Titans when Cortex spits scalding hot tea at him. He seems to be very grumpy and grouchy in his mutant form in Crash: Mind Over Mutant. At the beginning of the Crash series, he was a successful masseur, but slowly turned into a clumsy failure. Dr. Robotnik/Eggman (Sonic the Hedgehog) -
is an obese scientist with an IQ of 300; he has a dream of dominating the world. Eggman's constant plots to create his Empire are endlessly thwarted by Sonic the Hedgehog, his arch-enemy, and Sonic's friends. General Specific (Sheep in the Big City) -
is the main antagonist of the series.He is the dim witted leader of Secret Military Organization and keeps on trying to catch sheep for his sheep powered super laser but never can catch sheep.Zabuza (Naruto) -
In the past, Kirigakure had the practice of pitting Ninja Academy graduates against each other in a battle to the death for a final exam. After Zabuza, not yet a student himself, killed all one hundred of that year's students, the practice was discontinued. Zabuza would thereafter be known as the "Demon of the Hidden Mist". His fame grew over the years, as he became both an ANBU and a member of the Seven Ninja Swordsmen of the Mist, killing the Konohagakure ninja Kumade Toriichi during his career. At some point he discovered Haku, a child with a special kekkei genkai and began training him to be the ultimate weapon. In time he attempted to kill the Mizukage in a failed coup d'état, and subsequently fled with Haku and some other followers, such as the Demon Brothers.--
Save my Villain Day 52 (Spoilers) *NEW RULE http://www.gamefaqs.com/boards/8-gamefaqs-contests/63338550