Yeah Spekkio is really small.
Which means Luca Blight and Hayabusa and Sephiroth are going to destroy everyone but Wesker and X in short order with their superior melee skills and durability. Leon Kennedy is probably the best gunner here too speaking in terms of guns alone, as he actually has a good close range gun in the striker.
Huge durability advantage to team Sephiroth too. Seph, Luca, and Omnis are all tanky as hell and Hayabusa is really hard to hit at close range-- he'll be jumpin all over the place.
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No problem!
This is a cute and pop genocide of love!