I've gone for Crash/Cortex > Pac-Man/Blighty. Crash is stronger than people think, Neo Cortex is a memorable villain (see that 3-seed, and no B8 help either!) and I don't know how many people really see an individual ghost as Pac-Man's rival (I'd probably have picked Pac-Man if the entry was "Pac-Man vs. Ghosts" actually). Night match should help Euro-centric Crash too (remember that he outright beat Ryu H there). Think it has good "upset value" as a pick at least - few will take it.
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Praise the Black Turtle, Game of the Decade Guru Champ.
(Well, I never promised creativity, did I?!)