LogFAQs > #898153885

I'm game for mix and match in Dominion (Ascension too, actually) because I don't think many of the mechanics really NEED to show up in particular concentrations. Hmm...let's rank the expansions for fun.

Prosperity (Lots of my fave cards, and Colonies make games FEEL better because bigger numbers and more time for flashy engines to gel and go off)
Nocturne (Really interesting [but slightly random] mechanics, and some cool game-changers. Also, recency bias.)
Adventures (Several interesting mechanics)
Guilds (Some cool exclusive mechanics)
Hinterlands (Lots of niche cards that can do cool tricks)
Seaside (I like Durations as a mechanic, but a lot of kinda eh cards)
Dark Ages (Yay for trashing. And just plain weird.)
Adventures (Landmarks are a shake-up the game needs if you've been playing forever, but the kingdom cards are kinda eh)
Cornucopia (Focus on variety fits my playstyle)
Alchemy (Cool cards but potions are awkward, so this suffers the worst from playing multiple sets)
Base (2nd > 1st) (Nothin' wrong with vanilla)
Intrigue (2nd > 1st) (Too many sloggy cards)
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Look at all those chickens
There's a hunger in the land, there's a reckoning still to be reckoned