LogFAQs > #979530939

One of the worst aspects of the main game is how brutal the sidequests are. Like, maximum "guide dang it!" levels. You have one save file (well... 1.5 you could argue) that autosaves, and when you advance the main story too far, ALL side quests that expire at that point instantly do and you're hosed. Especially since missing out on one sidequest in a series of them will lock you out of the later ones, too.
I missed out on both Quina and Meredith's entire quest lines my first playthru b/c of that. Shit is brutal. Quina's involves going past a bunch of really tough bandits (you can try to flee past them, but they are hard....) and Meredith's you won't even notice if you don't check the quest board in the first town near the start of the game.