Current Events > Is the saying beer before liquor never sicker true?

(+) Yeah! (+)

Beer before liquor never sicker, liquor before beer in the clear

It has less to do with the type of alcohol and more to do with the fact that when you drink beer you have 12-20 oz where as with liquor the drinks are smaller so you tend to drink more of them.
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liquor with whine, and you'll end up fine.
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There's a handful of reasons:
The beer makes you pee, thus the hard stuff hits when you're already dehydrated.
A couple or three beers will exhaust the liver's supply of acetaldehyde dehydrogenase, which causes the breakdown of the ensuing hard liquor over the next several hours to lead to an epic hangover as acetaldehyde accumulates.

The inverse is mitgated because beer is mostly water, restoring hydration a bit before you pee again. Mechanically taking longer to actually drink, while having a lower percentage of ethanol overall, inadvertently leads to a "taper-off" effect, allowing the liver a little bit of an opportunity to replenish acetaldehyde dehydrogenase, which may cause the resulting hangover to be slightly less disastrous.