Well it's definitely gotta launch with all the Gen 7 ports it's getting (Assassin's Creed, Darksiders, Batman, Ninja Gaiden) As for Nintendo's launch star, they've been working on Pikmin 3 since Brawl was announced so I wouldn't be surprised to see that at launch. Ubisoft's Killer Freaks looks like it'll be their Wii U Red Steel, in that it'll be a badly rushed new IP FPS for U launch. Hey, this is actually a combination of their Wii launch titles (Red Steel & Raving Rabbids) since it has alien Rabbid creatures in it!
Japan'll have Dragon Quest X though which is pretty big for them. Definitely no Western equivalent exclusive........ well, DQX isn't really exclusive either, but lol nobody buys Wii games anymore.
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SegMlCassieIsAmazingjhsux~>[64T2jampXDpikaness is awesome!8forgaMike RSmurf is too!
Wii U is going to have a killer app launch game, Nintendo has learned from the 3DS launch.
There's a suspicious lack of main series Mario games on the horizon, so I'd say a new 3D Mario is a good candidate, and if they manage to revitalize the series again like they did with Galaxy, it could easily be GOTY.