Current Events > Caffeine is terrible for energy

(+) Yeah! (+)

whats so bad about anxiety?

it makes you look at life and you ask yourself questions.

thats like saying spicy food is terrible because plants made it as a defense against predators

but that shit is good

eat more sugar,

but no fat

Capsaicin is not a drug though
Try decaf. Quit the drug, eat more sugar, but no fat

shut up nerd

No, do less of this

and why not

Read up what digestion is. It's breaking down carbs and proteins down to ultimately be glucose. Your brains fuel is sugar.

Fat (oil, grease, lipids) is junk long term energy but is why western nations are truly obese. Not sugar (or carbs) The fat you eat is the fat you wear.

This is in disregard of the digestion process being what makes that end-result glucose safe and good, instead of just spiking your blood sugar, destabilizing your hormones, and, if you keep up, getting diabetes.

It does not give you energy

incorrectomundo.

it blocks adenosine from being released and increases the release of adrenaline.

the adrenaline can give you anxiety, and the lack of adenosine can exacerbate said anxiety.

it gives you anxiety in a different manner than adrenaline does.

shut up nerd

I'm approaching two months on a diet high in carbohydrate (>80%) with plenty of added sugar. I've done bloodwork twice during this experiment. My blood glucose has been in the low 80s (mg/dl), HbA1c 5%, and triglycerides declining. Also, my TSH has gone from an average of well over 3 down to 1.1, by far the lowest I've ever recorded in over 10 years of testing, rendering my cold hands and feet a thing of the past after 20 years of dealing with them. Even walking outside in sub-zero (F) weather, I swear it feels about 30 degrees warmer to me.
So, I feel pretty good about sugar.
Caffeine is interesting to me. I think that for most people, in moderate amounts, it can be a good thing, and this in part because of its slightly toxic properties. Hormesis.
Unfortunately, I have definitely noticed that I do better without it, including getting more complete sleep starting two or three nights nights after giving it up. I used to consume it very liberally, in part motivated by the fact that I have a fast caffeine metabolism genotype (high CYP1A2 activity). But it turns out that the primary metabolite of caffeine, paraxanthine, which has similar effects to caffeine, itself is metabolized mostly (about two thirds) by a different enzyme, 2A6, which I do not produce at all because of a rare genetic variant. So, my 1A2 has to do the double duty of breaking down caffeine and its byproduct, which may extend the quarter life of systemic effects of caffeine consumption to days.
My 2A6 genotype with effectively zero activity of the enzyme is rare, but there is a minority with reduced activity who probably also shouldn't be taking caffeine very often. I suspect low 2A6 activity is disproportionately high in people who become very enthusiastic about caffeine avoidance.

Variants of CYP2A6 are usually explored for their relationship to smoking. People with low activity of the enzyme are less likely to smoke cigarettes and find it easier to quit because they convert less nicotine to cotinine, its psychoactive byproduct. In my case, I convert none. When I found that out it really made sense: I had experimented with Swedish tobacco, nicotine gum, and vaping in the past, and never felt anything from it.

I'm approaching two months on a diet high in carbohydrate (>80%) with plenty of added sugar. I've done bloodwork twice during this experiment. My blood glucose has been in the low 80s (mg/dl), HbA1c 5%, and triglycerides declining. Also, my TSH has gone from an average of well over 3 down to 1.1, by far the lowest I've ever recorded in over 10 years of testing, rendering my cold hands and feet a thing of the past after 20 years of dealing with them. Even walking outside in sub-zero (F) weather, I swear it feels about 30 degrees warmer to me.
So, I feel pretty good about sugar.
Caffeine is interesting to me. I think that for most people, in moderate amounts, it can be a good thing, and this in part because of its slightly toxic properties. Hormesis.
Unfortunately, I have definitely noticed that I do better without it, including getting more complete sleep starting two or three nights nights after giving it up. I used to consume it very liberally, in part motivated by the fact that I have a fast caffeine metabolism genotype (high CYP1A2 activity). But it turns out that the primary metabolite of caffeine, paraxanthine, which has similar effects to caffeine, itself is metabolized mostly (about two thirds) by a different enzyme, 2A6, which I do not produce at all because of a rare genetic variant. So, my 1A2 has to do the double duty of breaking down caffeine and its byproduct, which may extend the quarter life of systemic effects of caffeine consumption to days.
My 2A6 genotype with effectively zero activity of the enzyme is rare, but there is a minority with reduced activity who probably also shouldn't be taking caffeine very often. I suspect low 2A6 activity is disproportionately high in people who become very enthusiastic about caffeine avoidance.

Variants of CYP2A6 are usually explored for their relationship to smoking. People with low activity of the enzyme are less likely to smoke cigarettes and find it easier to quit because they convert less nicotine to cotinine, its psychoactive byproduct. In my case, I convert none. When I found that out it really made sense: I had experimented with Swedish tobacco, nicotine gum, and vaping in the past, and never felt anything from it.

I'm approaching two months on a diet high in carbohydrate (>80%) with plenty of added sugar. I've done bloodwork twice during this experiment. My blood glucose has been in the low 80s (mg/dl), HbA1c 5%, and triglycerides declining. Also, my TSH has gone from an average of well over 3 down to 1.1, by far the lowest I've ever recorded in over 10 years of testing, rendering my cold hands and feet a thing of the past after 20 years of dealing with them. Even walking outside in sub-zero (F) weather, I swear it feels about 30 degrees warmer to me.
So, I feel pretty good about sugar.
Caffeine is interesting to me. I think that for most people, in moderate amounts, it can be a good thing, and this in part because of its slightly toxic properties. Hormesis.
Unfortunately, I have definitely noticed that I do better without it, including getting more complete sleep starting two or three nights nights after giving it up. I used to consume it very liberally, in part motivated by the fact that I have a fast caffeine metabolism genotype (high CYP1A2 activity). But it turns out that the primary metabolite of caffeine, paraxanthine, which has similar effects to caffeine, itself is metabolized mostly (about two thirds) by a different enzyme, 2A6, which I do not produce at all because of a rare genetic variant. So, my 1A2 has to do the double duty of breaking down caffeine and its byproduct, which may extend the quarter life of systemic effects of caffeine consumption to days.
My 2A6 genotype with effectively zero activity of the enzyme is rare, but there is a minority with reduced activity who probably also shouldn't be taking caffeine very often. I suspect low 2A6 activity is disproportionately high in people who become very enthusiastic about caffeine avoidance.

Variants of CYP2A6 are usually explored for their relationship to smoking. People with low activity of the enzyme are less likely to smoke cigarettes and find it easier to quit because they convert less nicotine to cotinine, its psychoactive byproduct. In my case, I convert none. When I found that out it really made sense: I had experimented with Swedish tobacco, nicotine gum, and vaping in the past, and never felt anything from it.

whats so bad about anxiety?

Capsaicin is not a drug though

then, why is it addictive?

i like drugs

Although caffeines best purpose is definitely as a pair up with aspirin. It gives the aspirin superpower qualities in getting rid of headaches.

Awesome man. What made you make the change? How are HDL and LDL levels? I get routine blood work done too