Yeah, I'm pretty sure the character of Calmasis is supposed to draw a lot of paralels between UU and Karkat. The whole androgynous thing could also even be a way for people to associate both a masculine Karkat and a feminine (guessing) UU.
Then again, as far as we know, this could be hinting at the Homestuck plot pitting the kids from our other universes against the trolls from this set, possibly even including UU as an antagonist. Zazzerpan and Calmasis may have swapped roles depending on which universe the story was written, etc. If it didn't at least have some kind of relevance, it probably wouldn't have gotten this much coverage (especially with the caduceus in the story title) in more than just the usual fashion we get SBAHJ references.
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Soft kitty, warm kitty, little ball of fur
Happy kitty, sleepy kitty, purr purr purr