LogFAQs > #882885018

I couldn't name an absolute favorite comedy. Off the top of my head there's School Rumble, Genshiken, Tonari no Seki-kun, anything by Hattori Mitsuru because he's got a bizarre sense of humor (I wasn't really crazy about Sankarea though).

One of my definite favorites is Otaku no Musume-san. I remember a few people here read it, but I wanna recommend it again. A comedy/slice of life/drama about a 30 year old otaku who finds out he has a daughter, who promptly moves in with him in an apartment building filled with weirdos. Hilarity, shame (fueled by hentai/eroge and a lolicon neighbor), growth and drama ensue.

It's damn good, but be prepared for occasional mood whiplash; it can switch from gut busting comedy to a punch in the feels at the drop of a hat, sometimes in the same chapter.
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Official King of PotD
You only need one T-Rex to make the point, though. ~ Samus Sedai