Dark Souls (Watch some videos, you'll probably be able to tell if it's something you want or not. If it is, you'll love it. Demon Souls would be good too, I'd assume, but I don't have a PS3 myself.)
Deus Ex: Human Revolution
Mass Effect 2
Fallout: New Vegas
Saints Row 2/3
Red Dead Redemption
Dead Rising 2
Assassin's Creed 2
Super Street Fighter 4 AE
Portal 2 (And the Orange Box if you can't run Half-Life 2/Portal)
Alpha Protocol
Hard Corps: Uprising (PSN)
Would suggest you not get LoD or Heavy Rain.
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SuperNiceDog won the Guru contest. Good job.