LogFAQs > #980329511

Starks posted...

I'm hoping that electrodes directly through the dura can mitigate this.

I think you get scar tissue issues no matter where the electrodes are placed into brain issue.

The paragraph below is from a 2023 lit review on Implantable intracortical microelectrodes.

https://www.nature.com/articles/s41378-022-00451-6

Tissue immune responses are divided into two phases. The early stage is the acute immune response due to mechanical damage caused by device insertion. The acute response is related to, among other factors, the size [53,54,55], insertion speed [56], tip shape, and surface roughness of the implantable electrode device [57]. Device insertion can damage or kill some of the neurons that are directly in contact with the device, forming a so-called kill zone, where the neuronal density is significantly reduced [57]. Macrophages (microglia) accumulate around the electrode during this stage, resulting in local neuronal toxicity. The second stage of the tissue response is the chronic immune response due to prolonged exposure to the device. The chronic response is mainly caused by the tethering mode [58,59], brain micromotion [60], and mechanical mismatch [61]. Implanted electrodes are generally fixed to the skull, but brain tissue is essentially floating in the skull [62]. As a result, a slight movement of the brain, typically caused by breathing, heartbeats, and external mechanical movements, could cause asynchronous movement between the electrodes and the brain tissue.

I recall reading similar stuff around 2016 or so when I researched this topic for a graduate class I was taking.