I'm familiar with a lot of the lore, or at least superficial amounts from Wikipedia articles and different forms of comic-related media, like cartoons and movies.
What ones are worth checking out? I know I'll end up checking out Batman, but I don't know much else besides that.
Animal Man, Batman, Wonder Woman, Action Comics, Swamp Thing, Frankenstein and Batwoman are all new-reader friendly and excellent. Demon Knights is great, too, but you should be familiar with the Jack Kirby and Alan Moore runs with the characters before you dive into the new book. There's a handful of other good books so far, but I wouldn't recommend a new DC reader a bunch of just good books. Go with the best to start, then pick out the rest.
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As for my personal recommendations on what has been both good AND accessible to new readers (bolded the ones I recommend the most):
Animal Man Action Comics Justice League Static Shock Batwoman Demon Knights Frankenstein: Agent of S.H.A.D.E. Resurrection Man Superboy Red Hood and the Outlaws Batman Blue Beetle Green Lantern Corps Nightwing Supergirl Wonder Woman
What's not out yet (releases this Wednesday):
All-Star Western Aquaman Batman: The Dark Knight Blackhawks Flash The Fury Of Firestorm: The Nuclear Men Green Lantern New Guardians I, Vampire Justice League Dark The Savage Hawkman Superman Teen Titans Voodoo
Also of note, if you go to the shop this week, the Week 3 books (see the chart below) are the least likely to be in stock, since Week 1 got reprints last week, and Week 2 gets them this week. Sales have been far higher than expected, so there have been issues with shortages.
Definitely throw Catwoman on there, very cool book. I also recommend Detective Comics, lotta people don't dig it but hey you might as well give the first issue a try, I dig it.
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You're late jumping on so it might be hard at this point.
I would recommend Justice League, Detective Comics, Animal Man, Swamp Thing, Batman and Robin, Resurrection Man, Deathstroke, Demon Knights, Superboy and Batman as the best ones out so far.
This week seems to have the most number of blockbusters though. Superman, Dark Knight, Aquaman, all sorts of potential greatness.