Current Events > Watch microglia dance around in the brain

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COVxy
05/30/21 11:21:30 AM
#1:


https://i.imgur.com/W9YpoPA.gif
These are averages taken across a 20-30 minute recording.

There's some motion in there, but the little cells that move quickly across the image are likely microglia. These cells are like the little recyclers of the nervous system. Picking up cell debris, repackaging unbound neurotransmitters. Pretty cool to watch them move around.

Went to bump the earlier topic and accidentally deleted it.

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Rexdragon125
05/30/21 11:25:40 AM
#2:


Neat. Wonder what kind of mental illnesses can result from them being unable to do their job.
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COVxy
05/30/21 11:36:41 AM
#3:


Rexdragon125 posted...
Neat. Wonder what kind of mental illnesses can result from them being unable to do their job.

They're involved in multiple sclerosis where they start attacking the insulation of neuron fibers.

But it's a good question how much either lack of function or dysfunction might contribute to complex disorders or neurological disease. I'm sure people study it, but I haven't read too much into it.

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COVxy
05/30/21 1:02:44 PM
#4:


Bump for science content.

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What_
05/30/21 1:04:20 PM
#5:


P cool. Packet switching for the brain
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teep_
05/30/21 1:06:16 PM
#6:


That's really cool
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COVxy
05/30/21 2:11:58 PM
#7:


This is a recording from the striatum of the mouse, a subcortical structure of the brain. It's roughly the input nucleus of the basal ganglia, it receives projections from the entire cortex, but only sends them within the basal ganglia system. It's thought that the basal ganglia helps gate behavior, which is why disorders of the basal ganglia tend to lead to uncontrollable behavior, either too much or too little, such as Huntington's disease and Parkinson's disease.

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COVxy
05/30/21 6:00:29 PM
#8:


This just popped up on my twitter feed, first 6-10 minutes is a good broad intro to the primate basal ganglia.
https://youtu.be/Br6s9_hCnWc

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COVxy
05/30/21 7:45:47 PM
#9:


The idea of the basal ganglia performing supervised dimensionality reduction is appealing. Action selection as a general problem seems to be almost necessarily defined as finding the action through a highly multidimensional space that maximizes reward.

It also must be the case that information is reduced through the circuitry.

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COVxy
05/31/21 8:40:35 AM
#10:


One last bump for science content.

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