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Antifar 07/23/22 8:14:33 AM #1: |
https://bit.ly/3zujRQ2 Last month, drug company Genentech reported on the first clinical trials of the drug crenezumab, a drug targeting amyloid proteins that form sticky plaques in the brains of Alzheimers disease patients. The drug had been particularly effective in animal models, and the trial results were eagerly awaited as one of the most promising treatments in years. It did not work. Crenezumab did not slow or prevent cognitive decline in people with a predisposition toward Alzheimers. tl;dr: the study "showing" what causes alzheimers appears to have used heavily doctored images to support its hypothesis. --- kin to all that throbs ... Copied to Clipboard!
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NeonOctopus 07/23/22 8:19:51 AM #2: |
Bruh what the fuck --- http://i.imgur.com/nlaY1qH.jpg http://i.imgur.com/zHJ1OCo.gif http://i.imgur.com/btBPP4E.jpg http://i.imgur.com/1B3bMHw.gif https://imgur.com/nQik2zW ... Copied to Clipboard!
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Turtlebread 07/23/22 8:20:22 AM #3: |
Alzheimers is caused by social media --- http://i.imgur.com/yCW15Zn.jpg ... Copied to Clipboard!
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teep_ 07/23/22 8:27:59 AM #4: |
disgusting --- A shepherd dressed in his Sunday finest still reeks of lamb! ... Copied to Clipboard!
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Questionmarktarius 07/23/22 8:30:18 AM #5: |
NeonOctopus posted... Bruh what the fuckGet the patent, sell pills for $1200 each. Who cares if you're wrong? ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 8:31:44 AM #6: |
A-beta plaques have long been shown to be pretty irrelevant to the primary pathology in Alzheimer's. This just further solidifies it. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 8:34:20 AM #7: |
Alzheimer's and Huntington's have nigh identical mechanisms. The origins are just different. ... Copied to Clipboard!
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DarkRoast 07/23/22 8:38:56 AM #8: |
Questionmarktarius posted... Alzheimer's and Huntington's have nigh identical mechanisms. The origins are just different. Sadly for huntington's, if you inherit the gene you're going to get it eventually. --- Lenovo Legion 7 - Ryzen 5900HX, RTX 3080 16 GB (165W), 32 GB DDR4-3200 By Grabthar's hammer............... What a laptop. ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 8:40:18 AM #9: |
Questionmarktarius posted... Alzheimer's and Huntington's have nigh identical mechanisms. The origins are just different. That's...not true at all. ... Copied to Clipboard!
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DarkRoast 07/23/22 8:41:16 AM #10: |
The_Psyence_Guy posted... That's...not true at all. I think he's basically saying that both are caused by deposition of protein into brain brain parenchyma, although by that definition Parkinson's and lewy body dementia would also apply. --- Lenovo Legion 7 - Ryzen 5900HX, RTX 3080 16 GB (165W), 32 GB DDR4-3200 By Grabthar's hammer............... What a laptop. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 8:42:01 AM #11: |
DarkRoast posted... Sadly for huntington's, if you inherit the gene you're going to get it eventually.The way the CAG repeat disaster works, you may actually die of something else, if you're within fourty repeats. ... Copied to Clipboard!
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DarkRoast 07/23/22 8:43:07 AM #12: |
Questionmarktarius posted... The way the CAG repeat disaster works, you may actually die of something else, if you're within fourty repeats. This is why prokaryotic DNA is better --- Lenovo Legion 7 - Ryzen 5900HX, RTX 3080 16 GB (165W), 32 GB DDR4-3200 By Grabthar's hammer............... What a laptop. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 8:45:12 AM #13: |
Human DNA is such a disaster that I don't know why we're still here. HeLa may well be our ultimate evolution. That shit is immortal. ... Copied to Clipboard!
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__aCEr__ 07/23/22 8:47:04 AM #14: |
That is truly awful. --- See you next Wednesday. ... Copied to Clipboard!
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DarkRoast 07/23/22 8:51:41 AM #15: |
Neurofibrillary tangles were the OG NFTs --- Lenovo Legion 7 - Ryzen 5900HX, RTX 3080 16 GB (165W), 32 GB DDR4-3200 By Grabthar's hammer............... What a laptop. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 8:53:39 AM #16: |
DarkRoast posted... I think he's basically saying that both are caused by deposition of protein into brain brain parenchyma, although by that definition Parkinson's and lewy body dementia would also apply.This. Crap proteins that don't get out the way, and just get in the way. Mutant Huntingtin is unique in that it eventually builds proteins measurable in millimeters. That's just catastrophic, in a brain. ... Copied to Clipboard!
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Trumpo 07/23/22 8:56:58 AM #17: |
As a someome who Judgment this hits hard --- Lancool II - Z690 Tomahawk, 12700K, Fuma 2, RTX 3070Ti, 16GB 3600MHz, FireCuda 530 1TB, Inland NVMe 1TB, RM750x ... Copied to Clipboard!
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haloiscoolisbak 07/23/22 8:57:29 AM #18: |
Well I'll be --- Started from the bottom now we here ... Copied to Clipboard!
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Questionmarktarius 07/23/22 9:04:18 AM #19: |
... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:05:31 AM #20: |
Questionmarktarius posted... @DarkRoast Huntington's is the odd one out, pretty much the only neurological condition with a known cause. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 9:06:51 AM #21: |
The_Psyence_Guy posted... Huntington's is the odd one out, pretty much the only neurological condition with a known cause.well, shit I guess we know where kuru and CJD come from. but those are especially terrible and fast compared to the rest ... Copied to Clipboard!
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DarkRoast 07/23/22 9:13:25 AM #22: |
Questionmarktarius posted... @DarkRoast Deposition of Lewy bodies (a waste protein) into various parts of the brain. Parkinson's involves deposition in the Basal Ganglia (movement) whereas Lewy Body Dementia is in the regions that manage behavior and information processing. --- Lenovo Legion 7 - Ryzen 5900HX, RTX 3080 16 GB (165W), 32 GB DDR4-3200 By Grabthar's hammer............... What a laptop. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 9:14:26 AM #23: |
DarkRoast posted... Deposition of Lewy bodies (a waste protein) into various parts of the brain. Parkinson's involves deposition in the Basal Ganglia (movement) whereas Lewy Body Dementia is in the regions that manage behavior and information processing.Do we have any idea why the "where" part is different? ... Copied to Clipboard!
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DarkRoast 07/23/22 9:15:02 AM #24: |
Questionmarktarius posted... Do we have any idea why the "where" part is different? My theory is that they're the same disease, but which one manifests first is person-specific. --- Lenovo Legion 7 - Ryzen 5900HX, RTX 3080 16 GB (165W), 32 GB DDR4-3200 By Grabthar's hammer............... What a laptop. ... Copied to Clipboard!
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Questionmarktarius 07/23/22 9:16:50 AM #25: |
What happens if you get asstons of lewys in the amygdala or cerebrum? Has that even happened yet? ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:25:00 AM #26: |
Questionmarktarius posted... What happens if you get asstons of lewys in the amygdala or cerebrum? Has that even happened yet? Parkinson's progresses from inside out, so the disease usually ends with dementia as it hits the cortex. More or less, eventually the whole brain is affected. ... Copied to Clipboard!
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indica 07/23/22 9:25:27 AM #27: |
teep_ posted... disgusting --- There is no good. There is no evil. There just is. ... Copied to Clipboard!
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Blightzkrieg 07/23/22 9:29:33 AM #28: |
Having independent studies replicate your results should be required before a study is taken seriously. Its a blatant gap in the current scientific review process and it's just going to get worse. There is so much research out there right now that things quickly turn into a game of telephone. --- http://i.imgur.com/1XbPahR.png ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:32:24 AM #29: |
Blightzkrieg posted... Having independent studies replicate your results should be required before a study is taken seriously. Its a blatant gap in the current scientific review process and it's just going to get worse. There is so much research out there right now that things quickly turn into a game of telephone. This would be prohibitively expensive, and often very very hard to do (some equipment can be in the hands of one or two labs in the world). ... Copied to Clipboard!
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gunplagirl 07/23/22 9:36:01 AM #30: |
The_Psyence_Guy posted... This would be prohibitively expensive, and often very very hard to do (some equipment can be in the hands of one or two labs in the world).This, and especially given how medication patents throw that for a loop in the United States. --- tfw no big tiddy goth vampire gf who lactates blood - viewmaster_pi ... Copied to Clipboard!
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Blightzkrieg 07/23/22 9:36:05 AM #31: |
The_Psyence_Guy posted... This would be prohibitively expensive, and often very very hard to do (some equipment can be in the hands of one or two labs in the world).Almost all research that gets done right now is a dead end being looked into for no reason "just in case". It wouldn't be that difficult to start looking into repeat studies for most things whenever a breakthrough is established. If we can do a thousand studies on the effects of sugar consumption, it's absolutely appalling that the root cause of Alzheimer's was established by a single study. --- http://i.imgur.com/1XbPahR.png ... Copied to Clipboard!
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Unsuprised_Pika 07/23/22 9:38:16 AM #32: |
"Last year, the Food and Drug Administration (FDA) narrowly approved the use of Aduhelm, a new drug from Biogen that the company has priced so highly that its expected to drive up the price of Medicare for everyone in America, even those who never need this drug" Holy fuck. For profit medicine really should be a crime against humanity. Individuals like Doctors and Nurses should be well compensated for their efforts and innovations but investors, companies and CEOS/Owners should not be making vast fortunes and no one even surgeons should be making fuck you money. --- I post clips of my Cool, Stupid and glitchy MH Rise/Sunbreak hunts here just for fun. https://youtube.com/user/linkachu1000 ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:38:20 AM #33: |
Blightzkrieg posted... it's absolutely appalling that the root cause of Alzheimer's was established by a single study. I mean, it wasn't. ... Copied to Clipboard!
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gunplagirl 07/23/22 9:41:43 AM #34: |
Unsuprised_Pika posted... "Last year, the Food and Drug Administration (FDA) narrowly approved the use of Aduhelm, a new drug from Biogen that the company has priced so highly that its expected to drive up the price of Medicare for everyone in America, even those who never need this drug"Also our medication patent laws need to be binned. At most, give the creators exclusivity rights for say, 10 years. After that, there'll be no charges or royalties paid for others to develop the same medication. And none of this "we refresh our rights by improving the formula and maybe one molecule pairing in the entire thing" crap to go after adjacent ones that have the same effects. --- tfw no big tiddy goth vampire gf who lactates blood - viewmaster_pi ... Copied to Clipboard!
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Blightzkrieg 07/23/22 9:44:51 AM #35: |
The_Psyence_Guy posted... I mean, it wasn't.This isn't my area of study so I'm going literally just based on the text of the article, which states that these plaques were assumed to be the immediate cause of memory deficits and most/many prospective Alzheimer's drugs work by targeting this plaque. All based on a fraudulent study. Please elaborate if that's incorrect. --- http://i.imgur.com/1XbPahR.png ... Copied to Clipboard!
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CE_gonna_CE 07/23/22 9:45:00 AM #36: |
I just watched Dopesick on Hulu yesterday. It really is so true, and sad, that this kinda stuff will never go away, unfortunately. --- https://gamefaqs.gamespot.com/boards/1531-food-delivery-services-general ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:45:33 AM #37: |
Blightzkrieg posted... This isn't my area of study so I'm going literally just based on the text of the article, which states that these plaques were assumed to be the immediate cause of memory deficits and most/many prospective Alzheimer's drugs work by targeting this plaque. All based on a fraudulent study. Please elaborate if that's incorrect. Antifar posted... The study didnt come out of nowhere; it only seemed to confirm one of several hypothesis about Alzheimers that had been circulating for many years by that point. After all, the brains of Alzheimers patients do contain plaques that can sometimes seriously alter the structure of the brain. Those plaques do contain amyloids. Its not much of a stretch to suggest those amyloids are a primary cause of the associated memory loss and dementia. Amyloids cause plaques, plaques cause damage, the damage causes Alzheimer's. QED. ... Copied to Clipboard!
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Blightzkrieg 07/23/22 9:47:18 AM #38: |
The article refers to that as being a hypothesis prior to the study in question, with the only actual supporting evidence being the fraudulent study. --- http://i.imgur.com/1XbPahR.png ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:50:38 AM #39: |
Blightzkrieg posted... The article refers to that as being a hypothesis prior to the study in question, with the only actual supporting evidence being the fraudulent study. That's a bit sloppy in both writing and interpretation. People had been working in both human and animal studies looking at amyloid long before that. This is just one study out of many. Like, amyloid plaques are highly present in patients, and it even correlates with disease severity. And if you create mouse lines that produce a lot of these plaques you get things that look like similar behavioral deficits. This is one mouse line, out of like dozens, and one study of that mouse line out of hundreds. ... Copied to Clipboard!
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The_Psyence_Guy 07/23/22 9:58:25 AM #40: |
Just to be clear though, it was pretty clear that A-beta was a deadend before those pharmaceutical companies started even developing those drugs. The failure of those clinical trials were just the final nails in the coffin. ... Copied to Clipboard!
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Blue_Thunder 07/23/22 10:01:05 AM #41: |
So is anyone working on research not based on this plaque stuff or did everyone jump on that bandwagon? --- aka Thunderjay - Jenshin Team: https://i.imgur.com/TtFLzT8.png Resident Synthwave enjoyer. ... Copied to Clipboard!
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COVxy 07/24/22 6:52:21 PM #42: |
https://gamefaqs.gamespot.com/a/user_image/7/9/5/AAZt-XAADfVr.jpg --- =E[(x-E[x])(y-E[y])] ... Copied to Clipboard!
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Tyranthraxus 07/24/22 6:55:29 PM #43: |
The_Psyence_Guy posted... Huntington's is the odd one out, pretty much the only neurological condition with a known cause. We've more or less pinned down multiple sclerosis. It's a very recent development though. --- It says right here in Matthew 16:4 "Jesus doth not need a giant Mecha." https://i.imgur.com/dQgC4kv.jpg ... Copied to Clipboard!
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Homeless_Waifu 07/24/22 7:00:51 PM #44: |
Questionmarktarius posted... Human DNA is such a disaster that I don't know why we're still here.I wouldn't say human DNA is bad... Humans simply aren't meant to last very long, at least not without degradation. The older you get, the higher you are at risk to experience something serious. A few people are lucky and can live the rest of their lives without having to worry about it too much... But for the vast majority of people, something will come along eventually. --- I bought the Taito Egret II Mini just to play puchi carat ... Copied to Clipboard!
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COVxy 07/24/22 7:12:20 PM #45: |
Tyranthraxus posted... We've more or less pinned down multiple sclerosis. It's a very recent development though. Haven't heard any real new developments there, link? I'll say: MS is one of those diseases where there is a magical cure-all blasted across the internet with little to no good evidence every couple of years, so I would be a bit skeptical by default. --- =E[(x-E[x])(y-E[y])] ... Copied to Clipboard!
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Tyranthraxus 07/24/22 7:19:51 PM #46: |
COVxy posted... Haven't heard any real new developments there, link? I didn't say anything about a cure, just that we know the cause. The cause is.... Well it's a cascading pile of shit but you have nerve damage which is the result of demyelination which happens because of antibodies that are antagonistic to the myelin sheath and those antibodies get produced because your B-cells are infected with EBV and the T-Cells for whatever reason can't identify and kill the infected B-cells. There's still some people with MS that don't have EBV but it seems thoses cases are extremely rare so in their case it must be some other mechanism creating the hostile antibodies. I'll get you a link in a moment but you can probably find it yourself just by searching multiple sclerosis and Epstein Barr virus. --- It says right here in Matthew 16:4 "Jesus doth not need a giant Mecha." https://i.imgur.com/dQgC4kv.jpg ... Copied to Clipboard!
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COVxy 07/24/22 7:24:56 PM #47: |
Ohh, I know the study you're referring to. It wasn't super convincing to me. The big thing was that it was a very large prospective epi study, so they could look for antecedents, even for such small probability events. But could easily just be a spurious association. --- =E[(x-E[x])(y-E[y])] ... Copied to Clipboard!
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nfearurspecimn 07/24/22 7:26:05 PM #48: |
what a shock that mental illness would foster such abusers (to be clear I'm not talking about those diagnosed, but the diagnosers) --- Wake up. You have to wake up. *currently a preta/hungry ghost* Dai Grepher: I was wrong. My entire theory is incorrect. Zero Mission IS a remake of Metroid. ... Copied to Clipboard!
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Tyranthraxus 07/24/22 7:27:28 PM #49: |
COVxy posted... Ohh, I know the study you're referring to. It wasn't super convincing to me. The big thing was that it was a very large prospective epi study, so they could look for antecedents, even for such small probability events. But could easily just be a spurious association. Since the last major study published about 6 months ago there's been some tremendous success in treating MS by treating EBV instead. This is all super new stuff though and so we're still at least a few years away from curing anything but evidence that this is the main culprit keeps coming in like an avalanche and I will be very surprised if it doesn't pan out long term. --- It says right here in Matthew 16:4 "Jesus doth not need a giant Mecha." https://i.imgur.com/dQgC4kv.jpg ... Copied to Clipboard!
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Beast_Le_Chonk7 07/24/22 7:31:38 PM #50: |
Wtf --- Now listening: https://youtu.be/huwRf0t-FHg ... Copied to Clipboard!
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