Current Events > Ivermectin Peer Reviewed Meta-Analysis

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joe40001
07/06/21 5:10:01 AM
#251:


Here is the FDA justification to give Remdesivir to people. Not "say it might be helpful", not "stop advising against it", but full stop give it FDA (EUA) approval:

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214787Orig1s000Sumr.pdf

That's the bar for FDA approval for a big pharma drug, nobody in true honesty could say Ivermectin doesn't come close to that.

The main criticism is that the meta-analysis is bad because it was "cherry picked", ok cherry picked how? Prove it, the burden of proof on completely rejecting the possibility of a safe and potentially helpful drug is on the people trying to shut down all the data. You have the evidence it is good in the meta-analysis and all the studies, you can't just say "nuh-uh" and "cherry picked" and invalidate tons of good science. Idiots could just as easily do that with the vaccines, at some point you have to play fair, and if you are holding ivermectin to a completely higher standard than things that have more risk such as remdesivir you aren't talking in good faith. You are playing politics with a tool that could help save lives.

Why? Because it vaguely feels "republican"? Because CNN hasn't give you their blessing yet? I can understand people who are skeptical in general, I can understand people who are unskeptical in general, but I can't understand people who look at the data and honestly come to the conclusion that 100% remdesivir should be FDA approved and Ivermectin shouldn't even be considered.

There is no good faith intellectually honest way to come to that conclusion.

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DarkRoast
07/06/21 5:51:52 PM
#252:


Fyi, none of us actually use Remdesivir

Also, for the love of all that is tasty, please stop this crap. It informs no one

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C_Pain
07/06/21 5:54:15 PM
#253:


all studies are biased and bs!

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Shezarr
07/06/21 5:58:42 PM
#254:


Can we just warn him again

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UnholyMudcrab
07/06/21 5:58:57 PM
#255:


Shezarr posted...
Can we just warn him again
And actually let the topic purge this time

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joe40001
07/06/21 6:35:02 PM
#256:


DarkRoast posted...
Fyi, none of us actually use Remdesivir

If you had to give 1 to a patient Remdesivir or Ivermectin, which would you give?

Also, for the love of all that is tasty, please stop this crap. It informs no one

It informs anybody who is interested in knowing about promising studies into safe COVID treatments/preventions that are available to the people who can't otherwise get vaccinated, something we should all care about.

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DarkRoast
07/06/21 10:03:23 PM
#257:


If you had to give 1 to a patient Remdesivir or Ivermectin, which would you give

Dexamethasone

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#258
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DarkRoast
07/06/21 10:14:39 PM
#259:





TC's a shill for Big Pharma

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joe40001
07/07/21 7:26:22 AM
#260:


DarkRoast posted...
If you had to give 1 to a patient Remdesivir or Ivermectin, which would you give

Dexamethasone

That wasn't one of the options.

DarkRoast posted...



TC's a shill for Big Pharma

There is no good reason it should cost that much considering it's off patent and cheap to make.

But it's applications are more for places like India where they don't have major access to the vaccine and big pharma doesn't hike their prices on generics.

In fact there is a lot of data pointing to India already benefiting from widespread ivermectin use.

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#261
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COVxy
07/07/21 9:22:22 AM
#262:


Joe, "of course I can understand a scientific article, it's in English", numbers.

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DarkRoast
07/07/21 2:57:02 PM
#263:


https://twitter.com/GidMK/status/1412635850903486467?s=19

A review of all of the literature that found positive associations resulted in only two articles, both low quality, that actually showed this.


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teep_
07/07/21 3:10:00 PM
#264:


DarkRoast posted...
https://twitter.com/GidMK/status/1412635850903486467?s=19

A review of all of the literature that found positive associations resulted in only two articles, both low quality, that actually showed this.

Indeed, the entirety of the ivermectin benefit across all of the literature appears to come down entirely to these two pretty low-quality pieces of research

[...]

is extremely concerning that all of the benefit seen for ivermectin seems to come from just 2 studies

[...]

In the absence of new evidence (this meta-analysis doesn't really count), I reckon that the only reasonable stance is that we don't really know if ivermectin works, and probably should not be using it outside of clinical trials

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COVxy
07/07/21 3:35:12 PM
#265:


There's a misnomer here in that you could find a significant meta-analytic effect even if all of the individual studies found no significant effect.

I'd just say that, at best, what's being shown is weak evidence for a positive effect. Which certainly doesn't call for clinical use, never mind instead of vaccination.

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DarkRoast
07/07/21 3:54:55 PM
#266:


COVxy posted...
There's a misnomer here in that you could find a significant meta-analytic effect even if all of the individual studies found no significant effect.

I'd just say that, at best, what's being shown is weak evidence for a positive effect. Which certainly doesn't call for clinical use, never mind instead of vaccination.

Given that the evidence for dexamethasone is much stronger, and the drug itself is much cheaper, I can't think of a rational reason to prescribe Ivermectin instead.

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COVxy
07/07/21 4:08:08 PM
#267:


DarkRoast posted...
Given that the evidence for dexamethasone is much stronger, and the drug itself is much cheaper, I can't think of a rational reason to prescribe Ivermectin instead.

Like I said, I'm not saying there's good evidence to suggest clinical use here. Just that the fact that only two studies show a strong positive effect doesn't necessarily say anything important for the detection of any effect at all. All and all seems consistent with a weak positive effect that would require far more samples to really detect.

Never really been a fan of meta-analysis generally anyway. Seems too unreasonable to collapse data across a myriad of known and unknown differences. Sometimes they can be useful for documenting potential moderators that account for differences across the literature.

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DarkRoast
07/07/21 4:34:42 PM
#268:


It's also a problem when the meta-analysis has highly variable levels of study quality weighted equally

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Frolex
07/07/21 4:36:49 PM
#269:


joe40001 posted...
In fact there is a lot of data pointing to India already benefiting from widespread ivermectin use.

then why did they stop using it joseph?

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joe40001
07/07/21 4:37:27 PM
#270:


COVxy posted...
Joe, "of course I can understand a scientific article, it's in English", numbers.

Yes, and?

[LFAQs-redacted-quote]


I'm not doing a bit, there is a lot of bad faith gaslighting from the mainstream trying to shut down ivermectin. I'm not sure if the people attacking it in this topic are taking part in the gas lighting or have just fallen for it, but just like with lab leak it's clear from the evidence what is likely to be true, even if for some dumb reason a lot of the mainstream is pretending like it isn't.

DR was wrong about lab leak and never acknowledged it. They seem to not be the type of person who cares about factual truth.

Right now there's more data supporting ivermectin's safety and efficacy than there was for remdesivir when it got FDA approval. It's bad faith and dangerous for society itself to try to gaslight the idea that it couldn't be a useful tool in the fight against COVID.

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#271
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joe40001
07/07/21 4:42:12 PM
#272:


metallica846 posted...
All that seems like a bit.
When I have I done a bit? The MLK thing was a clear setup that I revealed obviously, it wasn't a bit.

The unfortunate reality is in these days for some reason the mainstream news has become somewhat captured such that things like lab leak which are obviously plausible get gaslighted into being called debunked and conspiracy and get literally banned from being discussed. It's not on me that society is currently fucked like this.

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Frolex
07/07/21 4:53:29 PM
#273:


joe40001 posted...
The unfortunate reality is in these days for some reason the mainstream news has become somewhat captured such that things like lab leak which are obviously plausible

people didn't shit on you because they don't think it's possible covid leaked from a lab. they shit on because you said it's the most likely source with zero evidence to support that claim. if you're gonna be a sad human, be a sad and honest human.

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DarkRoast
07/07/21 4:57:27 PM
#274:


joe40001 posted...
When I have I done a bit? The MLK thing was a clear setup that I revealed obviously, it wasn't a bit.

The unfortunate reality is in these days for some reason the mainstream news has become somewhat captured such that things like lab leak which are obviously plausible get gaslighted into being called debunked and conspiracy and get literally banned from being discussed. It's not on me that society is currently fucked like this.

Spreading misinformation and unverified BS in an era where misinformation and unverified BS is literally costing lives doesn't make you a victim.


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NightMarishPie
07/07/21 5:00:49 PM
#275:


This thread has given me even less faith in ivermectin.

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Ooooooranges
07/07/21 5:13:45 PM
#276:


Why are you trying to act intelligent while quoting a terrible meta analysis? It demonstrates how poor you are at interpreting literature.

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UnholyMudcrab
07/07/21 5:28:39 PM
#277:


Ooooooranges posted...
Why are you trying to act intelligent while quoting a terrible meta analysis? It demonstrates how poor you are at interpreting literature.

But he can read English. That's all you need to interpret literature.
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DarkRoast
07/07/21 5:34:41 PM
#278:


Dunning-Kruger. Simple as that. When you lack enough knowledge to be able to accurately recognize your lack of knowledge.

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g0ldie
07/07/21 9:36:04 PM
#279:


DarkRoast posted...
Dunning-Kruger. Simple as that. When you lack enough knowledge to be able to accurately recognize your lack of knowledge.
I'm reminded of this interview:

https://mobile.twitter.com/waltermasterson/status/1374029684242063368

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joe40001
07/09/21 3:13:27 AM
#280:


DarkRoast posted...
Spreading misinformation and unverified BS in an era where misinformation and unverified BS is literally costing lives doesn't make you a victim.

You were wrong about lab leak, constantly misunderstand, quote twitter blog posts as your defense and your best argument against peer reviewed meta-analysis is this handwavy nonsense about how it's "bad' in a way that would invalidate FDA approved drugs.

Most of your arguments are clearly just parroting people on twitter and it very much seems like while you accuse me of not being able to read the articles you never read any of them, let alone come up with an opinion that was not prepackaged for you.

In a few months I will likely be validated and you will, like lab leak come up with some BS excuse to pretend like you were never wrong even though you obviously were.

How about this, if you are so sure about your conclusions about ivermectin let's make a bet:

I bet you 50 dollars that in the next year the WHO will recognize ivermectin as a valid treatment and/or prophylaxis for COVID19, it will be something phrased to the effect that "growing/new evidence has shown that ivermectin could be a reasonable treament/prophylaxis for COVID19, due to it's demonstrable safety the WHO no longer advises against it's use" or better.

If they do indeed say this or better (a full throated endorsement) you have to pay me 50 dollars and say on CE "I, DarkRoast, was wrong to arrogantly dismiss joe40001 and ivermectin"

If they don't say this or better, I will owe you 50 dollars and you can pick what I have to say publically.

Once you let me know what that public statement will be, we can both lock in and then we can really see who is seeing the truth clearly and who is on the wrong side of Dunning-Kruger.

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#281
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DarthAragorn
07/09/21 3:14:12 AM
#282:


metallica846 posted...
Has the lab leak been fully confirmed?
no lol

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joe40001
07/09/21 3:19:42 AM
#283:


metallica846 posted...
Has the lab leak been fully confirmed?

Despite a LOT of effort there has been no evidence found to support natural origin.

There is a lot of evidence to support lab leak.
I recommend NPR's fresh air interview:
https://www.npr.org/2021/06/17/1007539626/did-covid-19-leak-from-a-lab-a-reporter-investigates-and-finds-roadblocks

Or the vanityfair article about it:
https://www.vanityfair.com/news/2021/06/the-lab-leak-theory-inside-the-fight-to-uncover-covid-19s-origins

I think at this point it is safe to say anybody who said it was "debunked" or "impossible" or (as DR phrased it) "As likely as JFK being assassinated by alien space lasers" was clearly wrong and out of line.

I do and always have allowed for the possibility that new information will somehow point to natural origin, but I knew from very early on that banning discussion of it as "debunked misinformation" was incorrect and very inappropriate.

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What_
07/09/21 4:08:56 AM
#284:


joe40001 posted...
Yes, and?
Its stupid and vaccine is better
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pinky0926
07/09/21 4:23:22 AM
#285:


This is the funniest fucking topic I've read on CE in a long time

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joe40001
07/09/21 4:30:30 AM
#286:


What_ posted...
Its stupid and vaccine is better

And for the people who don't currently have access to the vaccine or otherwise can't get it? We should shut down all other potential options because...?

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scar the 1
07/09/21 4:54:22 AM
#287:


pinky0926 posted...
This is the funniest fucking topic I've read on CE in a long time
well brace yourself because it will literally never end

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Frolex
07/09/21 6:17:46 PM
#288:


joe40001 posted...
Despite a LOT of effort there has been no evidence found to support natural origin.

This is complete horseshit btw, for the two people left out there on the planet somewhere that might make the mistake of taking anything joenumbers says seriously. The research that's been done into the virus so far all almost universally points to it having a natural origin and none of it has demonstrated that Covid 19 was man-made or even bears the markings of human tampering.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118693/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194821/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898912/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050477/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969828/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166400/
https://www.sciencedirect.com/science/article/pii/S0092867421007091

Literally the only actual piece of evidence in favor that of the lab leak that currently exits is that there is a lab in the same city the virus was first identified

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joe40001
07/10/21 4:59:32 AM
#289:


So, um, DarkRoast.

You got awful quiet there.

When it meant you could mercilessly insult my intelligence you went HAM on being sure ivermectin couldn't possibly be effective, but ever since I brought up this bet you haven't said a peep.

Kinda fishy.

I mean if you are so sure you are right, why wouldn't you take the bet? It's free money and you get me to publically admit I'm wrong when what I say doesn't happen.

Isn't that a guaranteed win if you are as sure as you claim?

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COVxy
07/10/21 5:21:55 AM
#290:


This is pathetic dude.

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UnholyMudcrab
07/10/21 5:29:12 AM
#291:


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joe40001
07/10/21 5:34:55 AM
#292:


COVxy posted...
This is pathetic dude.

Asking people to put some stakes behind their smug dismissiveness and insults?

It's free money if they are right, and they have been acting unflinchingly like they are right. They made it quite explicit that they believe I am dumb for believing what I believe.

If that's true, why not take the bet?

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COVxy
07/10/21 5:40:35 AM
#293:


You should get really into counter-strike, or playing cards, or something. Idk, something that has winners and losers, that has collectibles that can be lorded over other people.

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DezDroppedFreak
07/10/21 9:13:44 AM
#294:


>says they argue in good faith
>always devolves into trying to get someone to take a weird bet

joe40001 posted...
Kinda fishy.


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joe40001
07/10/21 9:19:23 AM
#295:


DezDroppedFreak posted...
>says they argue in good faith
>always devolves into trying to get someone to take a weird bet

I do argue in good faith.

Asking people who have been insulting because they are apparently infinitely sure of their position to actually stake something on their position is reasonable.

If the money is the dealbreaker we can make it just something where if they are right I have to publicly make a statement they decide and if I am right they have to say the thing I said earlier.

I'm trying to move this conversation from random insults to concrete reality checked truth. If they weren't just recreationally insulting but actually stand by what they claim to believe then this is a gauranteed win for them, unless of course the thing they claim is impossible happens. But since they know it's impossible that shouldn't be a concern for them.

If somebody is going to call others dumb and frankly act like an asshole, they should have to risk some part of their reputation on their factual claim with which they justify doing so, otherwise they are just a bully.

So yeah, unless you aren't really sure of your claims, DR. The bet is on the table, free money and a free opportunity to get me to have to publicly admit I was wrong on CE.

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DezDroppedFreak
07/10/21 9:22:11 AM
#296:


Falling back to making people take weird-ass bets is not arguing in good faith no matter how many paragraphs of garbage you type

in fact your follow-up proves you literally only care about being right and not actually learning anything

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Omnislasher
07/10/21 9:24:19 AM
#297:


welp regretting my two jabs now
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Frolex
07/10/21 9:25:38 AM
#298:


joe40001 posted...
they should have to risk some part of their reputation on their factual claim

this isn't fair, you have no reputation to lose anyway

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joe40001
07/10/21 9:28:20 AM
#299:


DezDroppedFreak posted...
Falling back to making people take weird-ass bets is not arguing in good faith no matter how many paragraphs of garbage you type

in fact your follow-up proves you literally only care about being right and not actually learning anything

What is bad faith about what I said?

What is bad faith about truth checking truth claims?

And yeah, if two people are in a debate (particularly one with insults being thrown), I would hope the people involved care if they are saying something true or not. I do, apparently DR doesn't.

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DezDroppedFreak
07/10/21 9:31:24 AM
#300:


joe40001 posted...
And yeah, if two people are in a debate (particularly one with insults being thrown), I would hope the people involved care if they are saying something true or not. I do, apparently DR doesn't.

1. this is fucking gamefaqs.gamespot.com not a debate
2. That is not what I meant and you know it

Again, weird-ass bets are usually a sign of bad faith tactics. The last time you did this you were literally trying to set up a gotcha

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